Thyroglobulin is a large glycosylated protein. Thyroxine (T3 and T4) synthesis occurs at specific tyrosine residues on thyroglobulin.

Immunohistochemical expression

Antibodies to thyroglobulin do not react with epithelial cells of the lung, breast, gastrointestinal tract, pancreas, kidney or with the carcinomas of these organs. A case of moderate immunoreactivity in one ovarian serous papillary carcinoma from a series of seventeen has been reported1.

Diagnostic utility


1Keen, C. E., Szakacs, S., Okon, E., Rubin, J. S., Bryant, B. M. CA125 and thyroglobulin staining in papillary carcinomas of thyroid and ovarian origin is not completely specific for site of origin Histopathology 1999;34:113-117

2Bejarano, P. A., Y. E. Nikiforov, et al. (2000). "Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms." Appl Immunohistochem Mol Morphol 8(3): 189-94.


This page last revised 3002006


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