14-3-3s

14-3-3sigma, a member of the 14-3-3 family is a putative tumour suppressor gene. It is thougth to play a cricial role in the G2 check point by sequestering Cdc2-cyclinB1¹.

Immunohistochemical expression

It is positive in myoepithelial cells of breast. There is frequently loss of expression in breast carcinoma but retention of positivity in metaplastic carcinoma of breast².

Loss of expression due to hypermethylation appears to be more common in small cell and large cell lung carcinoma than in other types¹.

Diagnostic utility

References

¹Osada H, Tatematsu Y, Yatabe Y, et al. Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers. Oncogene 2002; 21:2418-24

² Leibl S, Gogg-Kammerer M, Sommersacher A, et al. Metaplastic breast carcinomas: are they of myoepithelial differentiation?: immunohistochemical profile of the sarcomatoid subtype using novel myoepithelial markers. Am J Surg Pathol 2005; 29:347-53

This page last revised 27.5.2005.

14-3-3s

14-3-3sigma, a member of the 14-3-3 family is a putative tumour suppressor gene. It is thougth to play a cricial role in the G2 check point by sequestering Cdc2-cyclinB11.

Immunohistochemical expression

Diagnostic utility

14-3-3sigma, a member of the 14-3-3 family is a putative tumour suppressor gene. It is thougth to play a cricial role in the G2 check point by sequestering Cdc2-cyclinB1¹.