Annexin

The annexins are a family of calcium and phospholipid-binding proteins implicated in the pathogenesis of neoplasms. These include annexins I, II, V and VII.

Immunohistochemical expression

Annexin I positivity is lost in prostatic carcinoma:

negative

focally positive

diffusely positive

Normal prostatic epithelium

127/127¹

High-grade PIN

38/50¹

12/50¹

Prostatic carcinoma

Gleason 6

7/40¹

18/40¹

15/40¹

Gleason 7 or 8

22/27¹

5/27¹

Gleason 9 or 10

9/10¹

1/10¹

Diagnostic utility

Potentially of use in the differentiation of benign prostatic epithelium, PIN and prostatic carcinoma.

References

¹ Patton KT, Chen HM, Joseph L, et al. Decreased annexin I expression in prostatic adenocarcinoma and in high-grade prostatic intraepithelial neoplasia. Histopathology 2005; 47:597-601

This page last revised 4.3.2006.

		negative	focally positive	diffusely positive
Normal prostatic epithelium				127/127¹
High-grade PIN			38/50¹	12/50¹
Prostatic carcinoma	Gleason 6	7/40¹	18/40¹	15/40¹
	Gleason 7 or 8	22/27¹	5/27¹
	Gleason 9 or 10	9/10¹	1/10¹