CD4

Antibodies are effective on paraffin-embedded sections¹.

Immunohistochemical expression

Helper/inducer T lymphocytes, monocyte/macrophages and Langerhans' cells. It is not expressed by B cells. CD4 and CD8 are mutually exclusive. The current antibodies are reactive only with fresh or frozen tissue.

• some T-ALL/T-LBL

Diagnostic utility

Identifies Helper/inducer T lymphocytes. Most T cell lymphomas are CD4+/CD8-.

References

¹Leong A S-Y, Cooper K and Leong FJ W-M. Manual of diagnostic antibodies for immunohistology. 2nd edition, 2003

©SMUHT/PW Bishop