Superficial cervicovaginal myofibroblastoma

The description below is based on a report of 14 cases

Clinical features

A tumour located in lamina propria of the vagina (n=12) and cervix (n=2). Age range 40 to 74 years (median 58 years).

Macroscopic appearances

Tumours ranged from 1 to 6.5 cm (median 2.0 cm) in size. Many were polypoidal (n=10). They were soft to rubbery with a glistening mucoid or fleshy cut surface.

Histopathology

They were located in the lamina propria and domed the overlying epithelium, from which they were separated by a band of myxoid or oedematous stroma. The tumours were not encapsulated but were well demarcated. They were composed of a uniform population of spindled or stellate cells in a finely collagenous matrix with myxoid or oedematous foci. Cellularity varied from moderate to high. A few multinucleate cells were present. Mitotic activity was up to 2 per 50 HPF. There was a sieve-like pattern of spindled cells encircling small nodules of collagen. Two cases showed a focal storiform pattern. The cells did not show concentration around vessels. There were no cases showing necrosis. Mast cells were were in all cases and some showed scattered lymphocytes (n=9).

Immunohistochemistry

 

Vimentin

5/5

Desmin D33

13/13 (highlighting cytoplasmic processes)

oestrogen receptor

10/10

progesterone receptor

10/10

CD34

11/13 (highlighting cytoplasmic processes)

SMA

5/11

Muscle-specific actin

2/8

S-100

negative

EMA

negative

keratin (AE1/AE3 and CK1)

negative

   

 

Differential diagnosis

References

Laskin, W. B., Fetsch, J. F., Tavassoli, F. A. Superficial cervicovaginal myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract. Human Pathol 2001;32:715-725.

This page last revised 8.11.2001.