Clear cell sarcoma (malignant melanoma of soft parts)

S-100	15/151
HMB-45	15/151
Melan-A
Tyrosinase	6/151
Mitf	10/151
NSE	variable
Leu-7	variable

Cytogenetics

 There is a characteristic t(12;22)(q13;q12) translocation, resulting in a ATF1-EWS fusion product.

References

¹Miettinen M et al. Microphthalmia transcription factor in the immunohistochemical diagnosis of metastatic melanoma: comparison with four other melanoma markers. Am J Surg Pathol 2001;25:205-211.

©SMUHT/PW Bishop