Cytokeratin 7

The available antibody works on formalin-fixed, paraffin embedded tissue

Immunohistochemical expression

Cytokeratin 7 is a basic cytokeratin found on many glandular and transitional epithelia.

Cytokeratin 7 is usually present in adenocarcinomas of:

It is usually absent from:

conventional carcinoma

0/10

chromophobe carcinoma

9/9 strong membrane staining (7 diffuse and 2 focal),

oncocytoma

8/8 focal weak to moderate cytoplasmic staining without membrane accentuation

Diagnostic utility

References

1 ME Mathers et al. Investigation of cytokeratin 7 expression in chromophobe renal cell carcinoma. Abstract 181, Pathological Society of Great Britain and Ireland January 2001.

2 Jerome Marson, V., J. Mazieres, et al. (2004). "Expression of TTF-1 and cytokeratins in primary and secondary epithelial lung tumours: correlation with histological type and grade." Histopathology 45(2): 125-34.

©SMUHT/PW Bishop