Fibrous histiocytoma (dermatofibroma, sclerosing haemangioma, histiocytoma cutis, nodular subepidermal fibrosis, fibrous xanthoma)

Clinical features

Ceullar fibrous histiocytoma may rarely metastasis².

Immunohistochemistry

• alpha-1-antitrypsin positive

• factor XIIIa positive

Variants¹

• with architectural peculiarities:

  • deep penetrating
    
  • atrophic
    
  • aneurysmal
    
  • haemangiopericytoma-like
    
  • palisading
• cellular/stromal peculiarities
  • clear cell
    
  • granular cell
    
  • myofibroblastic
    
  • sclerotic
    
  • monster cell
    
  • ostoeclast-like giant cells
    
  • atypical (pseudosarcomatous)
    
  • haemosiderotic
    
  • cholesterotic
    
  • palisading
    
  • myxoid
    
  • lipidized "ankle-type"
• with both architectural and cellular/stromal peculiarities
  • epithelioid cell
    
  • cellular benign
    
  • with smooth muscle proliferation
    
  • multinucleate cell histiocytoma
    
  • cellular neurothekeoma
    
  • plexiform fibrohistiocytic
    
  • plexiform xanthoma

Differential diagnosis

• dermatofibrosarcoma protuberans

• malignant fibrous histiocytoma

References

¹Zelger, B. G., Alonje, E., Zelger, B. Myxoid dermatofibroma. Histopathology 1999;34:357-364

²De Hertogh, G., Bergmans, G., Molderez, C. and Sciot, R. Cutaneous cellular fibrous histiocytoma metastasizing to the lungs. Histopathology 2002;41:85-6.