Non-neoplastic serous salivary gland acini, bronchial serous glands, seminal vesicles and apocrine skin adnexa are immunoreactive4. Renal tubules, ovarian surface epithelium and urothelium are negative4. Staining is cytoplasmic, often with paranuclear enhancement in mammary carcinomas4. There is concordance between the immunoreactivity of primary breast carcinomas and their metastases4.
Breast carcinoma |
62-77% of cases1, 10/14 (breast carcinomas metastatic to ovary)3, 4/295, 80/1076 |
||
ductal carcinoma |
71/1192, 62/824 |
||
lobular carcinoma |
9/102, 8/154 |
||
ductal carcinoma in situ |
5/64 |
||
mucinous carcinoma |
1/24 |
||
Salivary gland tumours |
|
||
5/124 |
|||
1/64 |
|||
0/54 |
|||
adenocarcinoma, NOS |
5/334 |
||
Skin adnexal tumours |
positive1 |
||
eccrine carcinoma |
1/164 |
||
Vulval Paget's disease |
9/9 (6 in situ and 3 invasive)4 |
||
Prostatic carcinomas |
4/404 |
||
Pulmonary carcinomas |
2/352 |
||
Gastric carcinomas |
1/392 |
||
Colonic carcinoma |
0/252, 0/946 |
||
Pancreatic carcinoma |
0/292 |
||
Ovarian carcinoma |
0/292, 0/323, 0/866, 1/26 (epithelial carcinomas)4 |
||
Renal carcinomas |
0/452, 1/294 |
||
Bladder carcinomas |
1/674 |
||
Other carcinomas |
usually negative1 |
||
Various non-mammary carcinomas |
5%4 |
||
|
||||||
positive |
negative |
positive |
negative |
|||
GCDFP-15 |
positive |
12 |
11 |
8 |
8 |
|
negative |
4 |
10 |
2 |
7 |
||
|
GCDFP-15 |
GCDFP-24 |
GCDFP-44 |
||
well-differentiated |
5/13 |
3/13 |
5/13 |
||
moderately differentiated |
11/19 |
9/19 |
11/19 |
||
poorly differentiated |
8/25 |
8/25 |
6/25 |
||
total |
24/57 |
20/57 |
22/57 |
||
with apocrine differentiation |
7/9 |
5/9 |
6/9 |
Malignant pleural epithelioid mesothelioma |
0/218 |
||
Malignant peritoneal epithelioid mesothelioma |
0/208 |
||
Peripheral pulmonary adenocarcinoma involving pleura |
0/238 |
||
Serous surface papillary adenocarcinoma of peritoneum |
0/108 |
||
Breast carcinoma metastatic to pleura |
7/108 |
||
Identification of carcinoma as metastatic from breast.
References
This page last revised 19.8.2005.
©SMUHT/PW Bishop