Kaposi sarcoma-associated herpesvirus, KSHV

ORF73 is a gene product expressed during latent infection. vIL-6 and K8.1 are early lytic gene products. ORF59 is also a lytic antigen. Primary effusion lymphomas, including the extra-cavitary variant, show the pattern of latent infection (ORF73+ / ORF59- / vIL-6- / K8.1-).

KSHV infection is assocaited with Kaposi's sarcoma, plamsablastic lymphoma and germinotropic lymphoprliferative disease.

	HIV	B-cell antigens	CD30	EBV	peripheral blood involvement
Plasmblastic lymphoma	positive	positive	weak	always negative	yes	associated with multicentric Castleman's disease
classic PEL	positive	usually negative	positive
extra-cavitary PEL	positive	may be positive	positive	posiitve	np	rarely associated with multicentric Castleman's disease
Polyclonal germinotropic lymphoproliferative disease	negative	CD20 negative	negative	posiitve

References

¹Chadburn, A., E. Hyjek, et al. (2004). "KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma." Am J Surg Pathol 28(11): 1401-16.

This page last revised 20.12.2004.

©SMUHT/PW Bishop