Merkel cell carcinoma of the skin v metastatic small cell carcinoma of the lung

Use TTF-1 and CK20 in combination:

		TTF-1	CK 20
Merkel cell carcinoma of skin	Chan1	-	33/34
	Bryd-Gloster2	0/21	16/21
	Ordonez3	0/18	16/18
	Cheuk4	0/23	23/23
	Leech5	0/11	10/11
	Overall	0% (0/73)	92% (98/107)
Small cell carcinoma of lung	Chan1		1/37
	Bryd-Gloster2	35/36	1/36
	Ordonez3	27/28	1/28
	Cheuk4	43/52	0/52
	Leech5	10/10	0/10
	Overall	91% (115/126)	2% (3/163)

References

¹Chan JKC et al. Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol 1997;21:226-234.

²Bryd-Gloster A et al. Differential expression of thyroid transcription factor 1 in small cell lung carcinoma and Merkel cell tumor. hum Pathol 2000;31:58-62.

³Ordonez NG. Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas. Am J Surg Pathol 2000;24:1217-1223.

⁴Cheuk W et al. Immunostaining for thyroid transcription factor-1 and cytokeratin 20 aids in the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinoma. Arch Pathol Lab Med 2001;125:228-231.

⁵Leech, S. N., Kolar, A. J., Barrett, P. D., Sinclair, S. A., Leonard, N. Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1. J Clin Pathol 2001;54:727-729

This page last revised 27.12.2001.