OCT2 is a transcription factor in B-lymphocytes2, that targets the octomer motifs in the immunoglobulin promotor in conjunction with co-activator BOB.1, activating immunoglobulin gene transcription. It is thought to play a role in germinal centre formation and in the differentiation of B-cells into plasma cells.
Immunohistochemical expression
Expression is nuclear.
In non-neoplastic tissue, expression is seen in a B-cell distribution.
|
|
PU.1 |
BSAP |
Oct-2 |
||
|
15/151 |
15/151 |
15/151 |
|||
|
2/35 (RS cells in one case definitely positive, one case equivocal. In all cases, histiocytes and small B-cells were positive.)1 |
27/291 |
0/291 |
|||
|
6/61 |
2/21 |
3/31 |
|||
|
7/71 |
2/21 |
4/41 |
|||
|
2/31 |
2/21 |
4/61 |
|||
|
3/31 |
2/21 |
2/21 |
|||
|
11/181 |
9/101 |
15/171 |
|||
|
0/61 |
4/41 |
4/41 |
|||
|
B-cell non-Hodgkin lymphoma |
29/431 |
21/221 |
32/361 |
||
|
negative1 |
|
|
|||
|
0/171 |
0/171 |
|
|||
|
0/71 |
0/71 |
|
This page last revised 7.10.2006.
©SMUHT/PW Bishop