Oesophageal epithelium

Multilayered epithelium may be derived from mucosal gland duct epithelium and may be a progenitor of Barrett's epithelium. p63 may play a role in squamous neoplasia of the oesophagus but not Barrett's metaplasia and associated neoplasia.

Immunohistochemistry

	CK8/18	CK13	CK 14	CK19	p53	p63
normal squamous epithelium	0/17	18/18	19/19	16/16	0/20	20/20
dysplastic squamous epithelium	0/4	0/4	4/4	4/4	4/4	4/4
squamous carcinoma	0/7	0/7	7/7	7/7	5/7	7/7
oesophageal mucosal gland duct epithelium	10/10	3/10	0/9	10/10		10/11
oesophageal multilayered epithelium	9/9	6/9	0/9	9/9	4/13	9/13
intestinal metaplasia					0/10	0/10
glandular dysplasia					9/12	0/12
adenocarcinoma					4/7	0/7

References

Glickman, J. N., Yang, A., Shahsafaei, A., McKeon, F., Odze, R. D. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Human Pathol 2002;32:1157-1165

This page last revised 3.5.2002.

©SMUHT/PW Bishop