Osteopontin is overexpressed in carcinomas of lung, breast, colorectum, stomach and ovary, and in melanoma. High levels of expression correlate with tumour invasion, progression and metastases. Osteopontin is expressed by most mesotheliomas.
|
Organ |
tumour type |
Osteopontin |
|
Brain |
6/10 (5 astrocytomas, 3 glioblastomas, 2 meningiomas)2 |
|
|
Breast |
ductal carcinoma |
3/262 |
|
Larynx |
squamous cell carcinoma |
1/32 |
|
Lung |
12/17 ( 5/7 adenocarcinomas, 5/8 squamous cell carcinomas, 2 adenosquamous carcinomas)2 |
|
|
Mesothelioma |
Epithelial |
19/201 |
|
Mixed |
15/161 |
|
|
Sarcomatoid |
2/21 |
|
|
Overall |
36/38 (using a tissue microarray: at least 50% of cells were positive. Adjacent normal pleura and lung parenchyma were negative.)1 |
|
|
Lip |
squamous cell carcinoma |
7/92 |
|
Mouth |
squamous cell carcinoma |
12/192 |
|
Tongue |
squamous cell carcinoma |
14/222 |
|
Salivary gland |
3/14 (3 acinic cell carcinomas, 4 mucoepidermoid carcinomas, and 7 pleomorphic adenomas)2 |
|
|
Pharynx |
squamous cell carcinoma |
2/52 |
|
Oesophagus |
squamous cell carcinoma |
7/102 |
|
Stomach |
adenocarcinoma |
11/112 |
|
Colon |
adenocarcinoma |
17/202 |
|
Liver |
4/9 (1 hepatocellular carcinoma, 8 metastatic adenocarcinomas)2 |
|
|
Bile duct carcinoma |
1/12 |
|
|
Pancreas |
adenocarcinoma |
13/162 |
|
Ovary |
serous cystadenocarcinoma |
13/222 |
|
Endometrium |
adenocarcinoma |
10/142 |
|
Kidney |
renal cell carcinoma |
26/362 |
|
Renal pelvis |
transitional cell carcinoma |
14/172 |
|
Bladder |
transitional cell carcinoma |
33/332 |
|
Prostate |
adenocarcinoma |
12/282 |
|
Skin |
4/6 (4 melanomas, 2 basal cell carcinomas)2 |
|
|
Thyroid |
0/22 |
|
Potentially of use in the diagnosis of mesothelioma1. Serum levels are reportedly higher in those exposed to asbestos with mesothelioma than those without. Immunohistochemical positivity is common in mesothelioma1 but the corresponding studies of reactive mesothelium have not yet been done.
This page last revised 7.11.2005.
©SMUHT/PW Bishop