Sertoli-stromal cell tumour of the ovary

Epidemiology

Clinical features

This is a sex cord stroma-derived tumour of the ovary of young adults. These tumours are commonly virilising.

Histopathology

Tubular sex cord-like structures resemble the seminiferous tubules of the testis. There is a variable stromal component resembling Leydig cells.

Immunohistochemistry

 

 

Sertoli cell component

Stromal component

a-inhibin

diffusely positive

focally positive

Cam5.2

diffusely positive

negative

Vimentin

diffusely positive

diffusely positive

Oestrogen receptor

equivocal

equivocal

Progesterone receptor

diffusely positive

focally positive

Androgen receptor

equivocal

equivocal

 

 

Ultrastructure

The tubules have a composite structure of Sertoli cells and rete cells.

Prognosis

Well differentiated tumours are considered benign. Intermediate and poorly differentiated tumours may show malignant behavior.

References

Kato, N., Fukase, M., Ono, I., Matsumoto, K., Okazaki, E., Motoyama, T. Sertoli-stromal cell tumor of the ovary: immunohistochemical, ultrastructural, and genetic studies. Hum Pathol 2001;32:796-802

This page last revised 10.11.2001.

©SMUHT/PW Bishop