Sertoli-stromal cell tumour of the ovary

Epidemiology

Clinical features

This is a sex cord stroma-derived tumour of the ovary of young adults. These tumours are commonly virilising.

Histopathology

Tubular sex cord-like structures resemble the seminiferous tubules of the testis. There is a variable stromal component resembling Leydig cells.

Immunohistochemistry

Sertoli cell component Stromal component a-inhibin diffusely positive focally positive Cam5.2 diffusely positive negative Vimentin diffusely positive diffusely positive Oestrogen receptor equivocal equivocal Progesterone receptor diffusely positive focally positive Androgen receptor equivocal equivocal

Ultrastructure

The tubules have a composite structure of Sertoli cells and rete cells.

Prognosis

Well differentiated tumours are considered benign. Intermediate and poorly differentiated tumours may show malignant behavior.

References

Kato, N., Fukase, M., Ono, I., Matsumoto, K., Okazaki, E., Motoyama, T. Sertoli-stromal cell tumor of the ovary: immunohistochemical, ultrastructural, and genetic studies. Hum Pathol 2001;32:796-802

This page last revised 10.11.2001.

©SMUHT/PW Bishop