Sex cord-stromal tumour of testis, mixed and unclassified

Histopathology

There is incomplete differentiation, but recognisably of sex cord-stromal tumour type.

Immunohistochemistry

inhibin	2/52
CD99	1/52
S-100	4/43
SMA	4/43

Differential diagnosis

• A pure form of sex cord-stromal tumour.

Prognosis

• About 20% of adult cases show malignant behaviour

• Malignant behaviour is uncommon in childhood tumours.

References

¹Shanks JH, Iczkowski KA. Non-germ cell tumours of the testis. Current Diagnostic Pathology 2002;8:83-93.

²Kommoss, F., Oliva, E., Bittinger, F., Kirkpatrick, C. J., Amin, M. B., Bhan, A. K., Young, R. H., Scully, R. E. Inhibin-alpha CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome. Hum Pathol 2000;31:1055-61.

³Renshaw, A. A., Gordon, M., Corless, C. L. Immunohistochemistry of unclassified sex cord-stromal tumors of the testis with a predominance of spindle cells. Mod Pathol 1997;10:693-700.

This page last revised 2.12.2002.

©SMUHT/PW Bishop