Smad4, DPC4
Smad4 is a tumour suppressor gene
located at 18q21.1. It is inactivated in 55% of pancreatic adenocarcinomas1
and in 34% of carcinomas
of the Ampulla of Vater but not in the associated adenomas2.
Immunohistochemical expression
Diagnostic utility
References
1 Hahn
SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor
gene at human chromosome 18q21.1. Science 1996; 271:350-3
2 McCarthy
DM, Hruban RH, Argani P, et al. Role of the DPC4 tumor suppressor
gene in adenocarcinoma of the ampulla of Vater: analysis of 140
cases. Mod Pathol 2003; 16:272-8
This page last
revised 27.6.2005.
©SMUHT/PW Bishop