Positivity for TTF-1 in extra-pulmonary small cell carcinoma

The frequency of positivity for TTF-1 appears to vary between different anatomical sites:

orbit	0/14
sinonasal	0/83, 0/14, 1/1 (brain metastasis from paranasal sinus)5
thyroid	0/23, 1/12
salivary gland	0/23, 0/12, 0/14, 3/156, 1/3 (described as high-grade neuroendocrine tumours)8
thymus	0/34
larynx	1/14
gastrointestinal tract, NOS	2/123
oesophagus	5/74
stomach	2/44
small intestine	0/14, 1/2 (described as high-grade neuroendocrine tumours)8
appendix	0/17
colorectum	0/24, 1/7 (described as high-grade neuroendocrine tumours)8
liver	1/1 (described as high-grade neuroendocrine tumour)8
pancreas	0/13, 1/14
renal pelvis	1/14
urinary bladder	1/53, 2/41, 2/32, 1/34, 2/10 (described as high-grade neuroendocrine tumours)8
prostate	0/33, 4/41, 5/52, 1/34, 5/5 (described as high-grade neuroendocrine tumours)8
uterine cervix	1/33, 1/71, 0/12, 7/164, 2/3 (described as high-grade neuroendocrine tumours of uterus: the exact site is not clear)8
vagina	0/14
endometrium	0/14
breast	1/12, 1/24, 1/3 (described as high-grade neuroendocrine tumours)8, 2/109
adrenal	1/14

References

Ordonez NG. Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. Advances in Anatomic Pathology 2000; 7(2): 123-127.

¹ Agoff SN et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumours. Mod Pathol 2000;13:238-242.

² Kaufmann O & Dietel M. Expression of thyroid transcription factor-1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites. Histopathology 2000; 36: 415-420.

³ Ordonez NG. Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas. Am J Surg Pathol 2000;24:1217-1223.

⁴ Cheuk W et al. Immunostaining for thyroid transcription factor-1 and cytokeratin 20 aids in the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinoma. Arch Pathol Lab Med 2001;125:228-231. (supplemented by personal communication).

⁵ Srodon, M. and Westra, W.H. Immunohistochemical staining for thyroid transcription factor-1: a helpful aid in discerning primary site of tumor origin in patients with brain metastases. Hum Pathol 2002;33:642-5.

⁶ Nagao, T., T. A. Gaffey, et al. (2004). "Small cell carcinoma of the major salivary glands: clinicopathologic study with emphasis on cytokeratin 20 immunoreactivity and clinical outcome." Am J Surg Pathol 28(6): 762-70.

⁷ Rossi, G., F. Bertolini, et al. (2004). "Primary mixed adenocarcinoma and small cell carcinoma of the appendix: a clinicopathologic, immunohistochemical, and molecular study of a hitherto unreported tumor." Am J Surg Pathol 28(9): 1233-9.

⁸ Barbareschi, M., C. Roldo, et al. (2004). "CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors." Am J Surg Pathol 28(9): 1169-76.

⁹ Shin SJ, DeLellis RA,Rosen PP. Small cell carcinoma of the breast--additional immunohistochemical studies. Am J Surg Pathol 2001; 25:831-2

This page last revised 23.9.2005.

©SMUHT/PW Bishop