This is a lectin produced by the gorse plant. It recognises the Fuc-alpha-1-2-Gal linkage in fucosylated oligosaccharides. UEA1 binds the H blood group antigen, CEA and a fucosylated protein on endothelium. Its use in immunohistochemistry requires either biotinylation of the lectin or the use of a biotinylated anti-Ulex antibody.
Reactivity
Vascular tumours: sensitivity is high but specificity is low.
some carcinomas
References
Diagnostic Immunohistochemistry edited by Professor D. J. Dabbs, page 71
This page last revised 21.12.2001.
©SMUHT/PW Bishop