Endometrial versus endocervical carcinoma, Kamoi et al¹

"positive": score > 3	Endometrial				Endocervical				Conclusion
	endometrioid		mucinous		endometrioid		mucinous
	mean (range)	positive	mean (range)	positive	mean (range)	positive	mean (range)	positive
ER	5.7 (0-12)	20/27	4.2 (0-12)	9/17	1.6 (0-6)	1/5	0	1/10	score relates mainly to site
PR	7.6 (0-12)	24/27	2.8 (0-6)	7/17	6.0 (0-12)	3/5	0.1 (0-1)	1/10	score relates mainly to type
CK4	9.2 (0-12)		4.4 (0-12)		10.6 (8-12)		8.5 (6-12)		not useful
CK18	6.4 (0-12)		3.4 (0-8)		8.4 (6-12)		5.5 (0-12)		not useful
CK20	0.7 (0-12: score of 12 in one case)		0		0.4 (0-2)		0.5 (0-1)		almost always negative
CEA	0.4 (0-6)	2/27	0.9 (0-6)	1/17	1.2 (0-6)	1/5	5.1 (1-12)	5/10	scores highly only in some mucinous endocervical carcinomas
Vimentin	6.9 (0-12: glands 7.6, solid glandular 3.7, squamous 0)	24/27	1.9 (0-12: only one case > 6)	3/17	4.4 (0-12)	2/5	0	0/10	scores highly only in endometrial endometrioid carcinomas

Immunoreactivity was scored as for the German Immunohistochemical Scoring System:

percentage of positive cells (PPS); 0=negative, 1 = up to 10% positive, 2 = 11 to 50% positive, 3 = 51 to 80% positive, 4 = more than 800% positive

Staining intensity (SI); 0 = negative, 1 = weak, 2 = moderate, 3 = strong.

Score = PSS x SI (maximum score = 12). A score of 3 or less is essentially "negative".

References

¹Kamoi, S., M. I. AlJuboury, et al. (2002). "Immunohistochemical staining in the distinction between primary endometrial and endocervical adenocarcinomas: another viewpoint." Int J Gynecol Pathol 21(3): 217-23.

This page last revised 4.5.2004.

©SMUHT/PW Bishop