Inhibin and calretinin in ovarian tumours

Inhibin has greater specificity but calretinin greater sensitivity for ovarian sex cord-stromal tumours.

	inhibin	calretinin
Granulosa cell	37/391 4******** 3************** 2***** 1********** 0**	39/391 4************* 3************ 2*************** 1*** 0
Sertoli-Leydig	12/131 4**** 3***** 2***** 1** 0*	13/131 4******* 3** 2**** 1 0
Sertoli cell tumour	4/41	4/41
Thecoma	8/91	9/91
Fibrothecoma	11/141 4* 3** 2*** 1***** 0***	14/141 4**** 3* 2***** 1**** 0
Sclerosing stromal tumour	2/21	2/21
Steroid cell	3/31	3/31
other stromal tumours	3/31	3/31
Sex cord-stromal neoplasms	80/871 4********************** 3*********************** 2******************* 1******************** 0*******	87/871 4************************************ 3***************** 2************************* 1********* 0
fibroma	3/201	19/201
adenofibroma	0/91	6/9 (stromal component only)1
fibrosarcoma	5/81	8/81
Fibrous neoplasms	8/371 4* 3** 2** 1*** 0*****************************	33/371 4*** 3*** 2*********** 1**************** 0****
Serous carcinoma	1/111	3/111
Atypical mucinous tumour	0/191	6/191
Clear cell carcinoma	0/71	1/71
Endometrioid carcinoma	0/151	3/151
Brenner tumour	0/131	1/13 (epithelial component only)1
Epithelial tumours	1/651	14/65 (13 cases: 1+, 1 case 4+)1
Dysgerminoma	0/71	0/71
Yolk sac tumour	0/51	0/51
Choriocarcinoma	0/11	0/11
Embryonal carcinoma	0/11	0/11
Immature teratoma	0/41	0/41
Mixed germ cell tumour	0/41	0/41
Germ cell tumours	0/221	0/221
Mixed Mullerian tumours	0/21	0/21
Small cell carcinoma	0/11	0/11
Clear cell sarcoma	0/11	0/11

4: >75% of cells, 3: 50-75% of cells, 2: 25-50% of cells, 1: <25% of cells. Each asterisk denotes one case.

References

¹Movahedi-Lankarani, S. and Kurman, R.J. Calretinin, a more sensitive but less specific marker than alpha- inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases. Am J Surg Pathol 2002;26:1477-83.