Ossifying fibromyxoid tumour of soft parts

Clinical features

This is most commonly a tumour of the subcutis or skeletal muscle of extremities. This is a tumour of borderline / low grade malignancy

Histopathology

It is composed of lobulated nests of small bland round cells within a stroma which varies form myxoid to hyaline. Most, but not all, cases have an incomplete shell of lamellar bone.

Immunohistochemistry

S-100	strongly and diffusely positive
vimentin	strongly and diffusely positive
CD57	most cases
NSE	most cases
GFAP	some cases
desmin	may be positive
SMA	may be positive
cytokeratin	negative
EMA	negative
HMB-45	negative

References

Diagnostic Immunohistochemistry edited by Professor D. J. Dabbs, pages 77

This page last revised 24.12.2001.

©SMUHT/PW Bishop