It is expressed in normal tissues undergoing proliferation and remodelling, such as during embryogenesis, morphogenesis, wound healing and angiogenesis. It is expressed by endothelium.
Overexpression by tumour cells has been reported in various malignancies including breast carcinoma, melanoma, glioma, meningioma, osteosarcoma and MFH. In colorectal and hepatocellular carcinoma, osteonectin is expressed by tumour-associated stromal cells but not by tumour cells themselves. Overexpression correlates with tumour progression and metastasis and inversely with patient survival.
clear cell |
0/1 |
papillary |
0/1 |
chromophobe |
0/1 |
sarcomatoid |
8/8 |
References
This page last revised 28.12.2001.
©SMUHT/PW Bishop