pax gene products
The
pax (paired box) genes are oncodevelopmental genes regulating
transcription and cellular differentiation. They share a DNA-binding
motif and are conserved in evolution5.
Immunohistochemical expression
References
1
Daniel, L., Lechevallier, E., Giorgi, R., Sichez, H.,
Zattara-Cannoni, H., Figarella-Branger, D., Coulange, C. Pax-2
expression in adult renal tumors. Human Pathol 2001;32:282-287
2
Sorensen, P. H., Triche, T. J. Gene fusions encoding chimaeric
transcription factors in solid tumours Semin Cancer Biol 1996;7:3-14.
3
Tagge, E. P., Hanson, P., Re, G. G., Othersen, H. B., Jr., Smith, C.
D., Garvin, A. J. Paired box gene expression in Wilms' tumor. J
Pediatr Surg 1994;29:134-141
4
Nikiforova, M. N., P. W. Biddinger, et al. (2002).
"PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and
immunohistochemical analyses." Am J Surg Pathol 26(8): 1016-23.
5
Dong HY, Liu W, Cohen P, et al. B-cell specific activation protein
encoded by the PAX-5 gene is commonly expressed in merkel cell
carcinoma and small cell carcinomas. Am J Surg Pathol 2005; 29:687-92
This page last
revised 16.8.2005.
©SMUHT/PW Bishop