adenocarcinoma

mesothelioma

Latza 199011

40/49(various sites of origin)

0/2

Kuhlmann 199116 (study done on cell blocks prepared from serous fluid)

18/20(various sites of origin)

3/20

Sheibani 19921

72/83

1/115(all histological types)

Gaffy 199212

103/120(various sites of origin. staining was membranous; diffuse in 82 and focal in 21 cases)

10/49(6/32 epithelioid and 4/17 biphasic: staining was restricted to the epithelioid areas and was generally focal; in one epithelioid case, there was positivity of the majority of tumour cells)

Moch 199317

34/34(pulmonary adenocarcinomas)

2/27(all histological types; staining was focal in 2 cases)

Dejmek 199418

28/42(various sites of origin)

14/93

Grove 199419

16/19(various sites of origin)

8/39(epithelioid or biphasic types)

Maguire 199420 (study done on cell blocks prepared from serous fluid)

45/63(13/23 pulmonary adenocarcinomas and 32/40 variously from breast, gastrointestinal tract, ovary, endometrium, and kidney)

2/44

Shield 199421 (study done on cell blocks prepared from serous fluid)

33/102(various sites of origin)

0/6

Ascoli 199522 (study done on cell blocks prepared from serous fluid)

145/152(various sites of origin)

0/33

Atanoos 199523

7/20(renal cell carcinomas)

1/20

Doglioni 199613

22/22(these were pulmonary adenocarcinomas: all showed staining of more than 50% of cells.)

2/20(two cases weakly positive.)

Bailey 199624 (study done on cell blocks prepared from serous fluid)

11/11(pulmonary adenocarcinomas: all showed intense membrane staining)

0/5

Kuenen-Boumeester 199625 (study done on cell blocks prepared from serous fluid)

56/56(various sites of origin)

7/8(variable membranous staining)

Bateman 19972

9/14(primary and secondary adenocarcinomas within lung and pleura.)

1/17

Dejmek 19973

28/43

14/110

Riera 19974

135/211(various sites of origin)

0/57(all of epithelioid type)

Delahaye 199726 (study done on cell blocks prepared from serous fluid)

69/88(various sites of origin)

1/41

Ordonez 199727

38/38(pulmonary adenocarcinomas)

9/50

Wilson 199728

9/9(lung and ovarian carcinomas)

4/21

Chenard-Neu 19985

30/30(various sites of origin)

4/28

Leers 199814

19/21(various sites of origin. 17 cases showing staining of >10% of cells, 2 cases showed staining of <10% of cells.)

7/20( 4 cases showing staining of >10% of cells, 3 cases showed staining of <10% of cells.)

Garcia-Prats 199829

16/18(13/15 pulmonary and 3/3 extrapulmonary)

1/40(0/26 epithelioid, 0/10 sarcomatoid, 1/4 biphasic)

Ordonez 199830

101/110(20/20 pulmonary adenocarcinomas {staining diffuse], 55/59 non-pulmonary adenocarcinomas [variable extent of staining] and 26/31 adenocarcinomas of unknown origin [variable extend of staining]: all were metastatic to pleura)

18/70(all epithelial pleural mesotheliomas: restricted to a limited number of cells)

Brockstedt 20006

40/57

19/119

Dejmek 200031 (study done on cell blocks prepared from serous fluid)

51/53(various sites of origin)

6/36

Gonzalez-Lois 20017

11/13(various sites of origin)

6/44(6/34 epithelioid, 0/6 sarcomatoid, 0/1 mixed and 0/1 lymphohistiocytoid mesotheliomas)

Harper 20018

12/18

5/112

Carella 20019

20/20(pulmonary adenocarcinomas)

4/46

Comin 200110

22/23(in 17 cases, staining was >75% of cells, in 5 cases 50-75% of cells.)

5/42(staining was always less than 25% of cells.)

Davidson 200132 (study done on cell blocks prepared from serous fluid)

94/98(various sites of origin)

4/12

Miettinen 200133

not studied

3/30(3/23 epithelioid and 0/7 sarcomatoid mesotheliomas)

Abutaily 2002 15

10/11

2/9

Ordonez 200334

50/50(all primary lung adenocarcinomas: 37 case >75% of cells stained, 13 cases 50-75% of cells, . Staining was both cytoplasmic and membranous. Well-differentiated cases tend to show preferential staining of the basolateral membrane with negativity of the apical membrane.)

11/60(epithelioid mesotheliomas: in 9 cases 1-25% of cells stained, in 2 cases <1% of cells stained)

Overall

80% (1394/1750)

12% (174/1445)