Aquasporins

Aquasporins are water-transporting proteins expressed by many epithelia and endothelium.

Immunohistochemical expression

Positive in:

• choroid plexus1

Negative in:

• Cerebellum1

Diagnostic utility

• Aquasporin 1: Diagnosis of CNS haemangioblastoma

References

1 Weinbreck N, Marie B, Bressenot A, et al. Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining. Am J Surg Pathol 2008; 32:1051-9

This page last revised 16.7.2008.

©SMUHT/PW Bishop