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CNS haemangioblastoma
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renal clear cell carcinoma
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Renal cell carcinoma marker
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0/711
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28/55(tumours metastatic to CNS)1
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Inhibin A
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20/222, 25/253,
66/67(most cases sowed granular cytoplasmic staining of the stromal cells: 1+: 2 cases, 2+: 5 cases, 3+: 13 cases, 4+: 46 cases)4
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5/21(positivity in 2 of 16 primary tumours and in 3 of 5 tumours metastatic to CNS)2,
0/19(15 primary tumours and 4 tumours metastatic to CNS)3,
16/34(1+: 6 cases, 2+: 3 cases, 3+: 3 cases, 4+: 4 cases)4
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CD10
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0/711, 0/222, 0/674
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46/54(tumours metastatic to CNS)1,
21/21(16 primary and 5 metastatic to CNS)2,
27/34(membranous staining: 1+: 4 cases, 2+: 2 cases, 3+: 9 cases, 4+: 12 cases)4,
85(of 102 primary tumours)%8
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EMA
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0/72, 0/63,
24/67(membranous staining of stromal cells: 1+: 11 cases, 2+: 7 cases, 3+: 3 cases, 4+: 3 cases)4
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34/34(1+: 1 cases, 3+: 11 cases, 4+: 22 cases)4
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NSE
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7/72, 9/93
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usually negative
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Aquasporin 1
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67/67(there is continuous membrane staining of stromal cells: 1+: 1 case, 2+: 1 case, 3+: 5 cases, 4+: 60 cases)4,
26/26(much stronger staining in cystic than in solid tumours)6,
10/10(this series of tumours were cystic )7
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13/34(1+: 3 cases, 2+: 4 cases, 3+: 4 cases, 4+: 2 cases)4,
78(of 102 primary tumours)%8
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AE1/AE3
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0/674
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30/34(staining is cytoplasmic: 2+: 3 cases, 3+: 6 cases, 4+: 21 cases. the four negative cases were also negative for 34bE12, CK8 and CK18)4
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D2-40
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13/67(continuous membrane staining: 1+: 5 cases, 2+: 4 cases, 3+: 1 case, 4+: 3 cases)4,
23/23(19 cases showed strong, membranous staining in the vacuolated tumor cells, and showed weaker staining: 3 cases had VHL of whom 2 had both haemangioblastoma positive for D2-40 and renal cell carcinoma negative for D2-40)5
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12/34(1+: 3 cases, 2+: 4 cases, 3+: 2 cases, 4+: 3 cases)4,
0/28(20 cases primary in the kidney, and 8 cases metastatic to the brain)5
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