CD43, leukosialin, sialophorin

CD43 is a transmembrane protein with functions in T-cell immunity. Leu22, DFT-1 and MT1 identify epitopes in formalin-fixed, paraffin embedded tissue2.

Immunohistochemical expression


Adenoid cystic carcinoma



Polymorphous low-grade adenocarcinoma


Monomorphic adenoma



Diagnostic utility

See: Comparison of sensitivities and specificities of T and B cell markers


1 M Steward et al. Production and characterization of a new monoclonal antibody effective in recognizing the CD3 T-cell associated antigen in formalin-fixed embedded tissue. Histopathology 1997;30:16-22.

2 Leong A S-Y, Cooper K and Leong FJ W-M. Manual of diagnostic antibodies for immunohistology. 2nd edition, 2003

3 Fernandez-Rodriguez J, Andersson CX, Laos S, et al. The leukocyte antigen CD43 is expressed in different cell lines of nonhematopoietic origin. Tumour Biol 2002; 23:193-201

4 Woo VL, Bhuiya T,Kelsch R Assessment of CD43 expression in adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, and monomorphic adenomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102:495-500


©SMUHT/PW Bishop