Carcinoma of the ampulla of Vater

Histopathology

Adenocarcinomas of the ampulla of Vater can be subdivided into intestinal type, pancreaticobiliary type and unusual type; the latter includes solid, undifferentiated signet ring cell tumours. Intestinal type consists of well formed tubules and cribriform areas, as seen in colorectal carcinoma. Pancreaticobiliary type consists of simple or branching glands and small nests within a desmoplastic stroma.

Immunohistochemistry

The Immunohistochemistry correlates with the morphological subtypes.

 

 

Intestinal type

Pancreaticobiliary type

Others

 

CK7

4/15

23/24

10/16

CK20

12/15

2/24

6/16

MUC1

9/15

20/24

13/16

MUC2

7/15

24/24

7/16

MUC15AC

6/15

16/24

9/16

CEA

8/15

7/24

12/16

Ca19.9

6/15

19/24

9/16

       

References

Zhou, H., N. Schaefer, et al. (2004). "Carcinoma of the Ampulla of Vater: Comparative Histologic/Immunohistochemical Classification and Follow-up." Am J Surg Pathol 28(7): 875-882.

This page last revised 18.7.2004.

©SMUHT/PW Bishop