Cytokeratin 7

The available antibody works on formalin-fixed, paraffin embedded tissue

Immunohistochemical expression

Cytokeratin 7 is a basic cytokeratin found on many glandular and transitional epithelia.

Cytokeratin 7 is usually present in adenocarcinomas of:

It is usually absent from:

Breast carcinoma

29/353

Ovarian serous

16/183

Ovarian mucinous

4/103

Endometrial adenocarcinoma

6/103

Pancreatic adenocarcinoma

51/533

Hepatocellular carcinoma

0/63

Ampulla of Vater

5/63

Cholangiocarcinoma

8/103

Gastric carcinoma

12/343

Oesophageal

adenocarcinoma

10/213

squamous cell carcinoma

0/73

Colonic adenocarcinoma

2/473

Prostatic adenocarcinoma

0/183

Lung

adenocarcinoma

42/463

small cell carcinoma

0/33

squamous cell carcinoma

3/73

Mesothelioma

4/63

Renal tumours

conventional carcinoma

0/101, 0/153

chromophobe carcinoma

9/9 strong membrane staining (7 diffuse and 2 focal)1

oncocytoma

8/8 focal weak to moderate cytoplasmic staining without membrane accentuation1

Diagnostic utility

References

1 Mathers ME, Pollock AM, Marsh C, et al. Cytokeratin 7: a useful adjunct in the diagnosis of chromophobe renal cell carcinoma. Histopathology 2002; 40:563-7

2 Jerome Marson, V., J. Mazieres, et al. (2004). "Expression of TTF-1 and cytokeratins in primary and secondary epithelial lung tumours: correlation with histological type and grade." Histopathology 45(2): 125-34.

3 Dennis JL, Hvidsten TR, Wit EC, et al. Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin Cancer Res 2005; 11:3766-72 FULL TEXT

 

©SMUHT/PW Bishop