Cytokeratin 7 is a basic cytokeratin found on many glandular and transitional epithelia.
Cytokeratin 7 is usually present in adenocarcinomas of:
Breast2
Ovary; serous and endometrioid tumours
Uterine cervical tumours
Biliary epithelium and cholangiocarcinoma
Transitional cell carcinoma of the bladder
It is usually absent from:
Squamous cell carcinomas
Hepatocytes and hepatocellular carcinoma
Prostate and prostatic adenocarcinoma
|
Breast carcinoma |
29/353 |
|
|
Ovarian serous |
16/183 |
|
|
Ovarian mucinous |
4/103 |
|
|
Endometrial adenocarcinoma |
6/103 |
|
|
Pancreatic adenocarcinoma |
51/533 |
|
|
Hepatocellular carcinoma |
0/63 |
|
|
Ampulla of Vater |
5/63 |
|
|
Cholangiocarcinoma |
8/103 |
|
|
Gastric carcinoma |
12/343 |
|
|
Oesophageal |
adenocarcinoma |
10/213 |
|
squamous cell carcinoma |
0/73 |
|
|
Colonic adenocarcinoma |
2/473 |
|
|
Prostatic adenocarcinoma |
0/183 |
|
|
Lung |
adenocarcinoma |
42/463 |
|
small cell carcinoma |
0/33 |
|
|
squamous cell carcinoma |
3/73 |
|
|
Mesothelioma |
4/63 |
|
|
Renal tumours |
0/101, 0/153 |
|
|
9/9 strong membrane staining (7 diffuse and 2 focal)1 |
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|
8/8 focal weak to moderate cytoplasmic staining without membrane accentuation1 |
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The coordinate expression of cytokeratins 7 and 20 is particularly useful in identifying the primary site of adenocarcinomas.
Renal carcinomas: differentiation of conventional carcinoma, chromophobe carcinoma and oncocytoma1.
Identification of ovarian granulosa cell tumours and differentiation from carcinomas (especially endometrioid carcinoma with a sex cord-like pattern)
References
2 Jerome Marson, V., J. Mazieres, et al. (2004). "Expression of TTF-1 and cytokeratins in primary and secondary epithelial lung tumours: correlation with histological type and grade." Histopathology 45(2): 125-34.
3 Dennis JL, Hvidsten TR, Wit EC, et al. Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin Cancer Res 2005; 11:3766-72 FULL TEXT
©SMUHT/PW Bishop