Combined small cell carcinoma

In combined small cell with non-small cell carcinoma of the lung, both components usually show the immunophenotype of small cell carcinoma.

Case1		synaptophysin	CD56	chromogranin	bcl-2	TTF-1	CK7	Pax-5
1	small cell component	strong	strong	negative	strong	strong	strong	weak focal
1	adenocarcinoma component	strong	strong	negative	strong	strong	strong	weak focal
2	small cell component	strong	strong	negative	strong	negative	negative	strong
2	adenocarcinoma component	strong	weak focal	negative	strong	negative	negative	strong
3	small cell component	strong	strong	strong	weak focal	strong	strong	weak focal
3	adenocarcinoma component	strong	strong	strong	weak focal	strong	strong	weak focal
4	small cell component	strong	strong	strong	strong	negative	negative	negative
4	squamous cell component	strong	strong	weak focal	weak focal	negative	negative	negative
5	small cell component	strong	strong	weak focal	strong	strong	strong	negative
5	squamous cell component	strong	strong	weak focal	weak focal	strong	strong	negative
6	small cell component	strong	strong	negative	weak focal	negative	strong	strong
6	large cell neuroendocrine component	strong	strong	negative	weak focal	negative	strong	strong
7	small cell component	strong	strong	negative	strong	strong	strong	negative
7	large cell neuroendocrine component	strong	strong	negative	strong	strong	strong	strong