GATA-3 belongs to the GATA family of transcription factors (comprising six members: GATA-1 to GATA-6).  It is expressed exclusively in the luminal epithelial cell population of the mammary gland, being absent from myoepithelial cells. GATA-3 is necessary for the specification and maintenance of luminal cells. Positive GATA-3 expression is among the best predictors of ER-positive status.   Low GATA-3 protein expression is an independent predictor of tumour recurrence after treatment. GATA-3 expression was also strongly correlated with the luminal A subtype of mammary carcinomas1.

Immunohistochemical expression

  Breast ductal carcinoma 59/91 (detail)1  
Breast lobular carcinoma 24/241
Lung adenocarcinoma 0/1581
Lung squamous cell carcinoma 0/391


Diagnostic utility


1 Yang M, Nonaka D. A study of immunohistochemical differential expression in pulmonary and mammary carcinomas. Mod Pathol. 2010 May;23(5):654-61.


This page last revised 10.5.2010.

©SMUHT/PW Bishop