GCDFP-15 in primary lung adenocarcinoma

 A subset of primary adenocarcinomas of lung show positivity for GCDF-15; these tumours occur in both sexes and have a distinctive morphology with mucin production and co-expression of TTF-1.

Histopathology

The tumour has a acinar or cribriform architecture, often with a papillary component. At the periphery of the tumour, there may be lepidic spread. There is intra- and extra-cellular mucin. The tumour cells are large, columnar or polygonal with copious cytoplasm, eosinophilic or clear. Sometimes the cells appear apocrine. Nuclei are large and oval. Psammoma body formation may occur. The stroma may include a marked lymphocytic infiltrate.

Immunohistochemistry

11 of 211 of pulmonary adenocarcinomas were positive for GCDF-15: positive cases usually show staining of about 20% of tumour cells. In these GCDFP-15 positive tumours, other antibodies showed the following results:

 

TTF-1

9/111

 

CK7

11/111

CK20

4/111

Synaptophysin

7/111

ER

0/111

PR

0/111

   

 

References

1 Striebel JM, Dacic S,Yousem SA. ross cystic disease fluid protein-(GCDFP-15): expression in primary lung adenocarcinoma. Am J Surg Pathol 2008; 32:426-32

 

This page last revised 26.4.2008

©SMUHT/PW Bishop