High mobility Genes, HMGA

The HMG proteins are small acidic non-histone chromatin-proteins. They include:

High mobility group genes HMGA1 and HMGA-2 are found in a wide range of benign mesenchymal tumours. In benign tumours, the HMGA genes show increased expression without structural alterations. They regulate chromatin architecture and gene transcription. HMGA1 is located at 6q21, HMGA2 at 12q14-15.


1 Hess JL. Chromosomal translocations in benign tumors: the HMGI proteins. Am J Clin Pathol 1998; 109:251-61