HMGA2, HMGIC

HMGA2 is a DNA-binding protein, a member of the high mobility group protein gene family3. The gene is aberrantly expressed in a range of mesenchymal neoplasms, in association with chromosomal translocations involving 12q15.

Immunohistochemical expression

• Neoplastic cells of aggressive angiomyxoma of the vulva1. Aberrant expression appears to be induced by t(8;12) translocation2.

NOT expressed in:

• Angiofibroblastoma1

• fibroepithelial stromal polyp1

Diagnostic utility

• Diagnosis of aggressive angiomyxoma of the vulva.

References

1Nucci, M. R., D. H. Castrillon, et al. (2003). "Biomarkers in diagnostic obstetric and gynecologic pathology: a review." Adv Anat Pathol 10(2): 55-68.

2Nucci, M. R., S. Weremowicz, et al. (2001). "Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva." Genes Chromosomes Cancer 32(2): 172-6.

3Kazmierczak, B., J. Rosigkeit, et al. (1996). "HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors." Oncogene 12(3): 515-21.

This page last revised 16.4.2004.

©SMUHT/PW Bishop