HSP70 is a member of the class of heat shock proteins, implicated in cell division, apoptosis and tumorigenesis.

Immunohistochemical expression

HSP70 is up-regulated in hepatocellular carcinoma1.

Diagnostic utility

Along with Glypican-3, HSP70 may be useful in the differentiation of benign from malignant liver nodules.


1 Di Tommaso L, Franchi G, Park YN, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 2007; 45:725-34


This page last revised 29.4.2008.

©SMUHT/PW Bishop