The melanoma antigen-encoding gene (MAGE) family consists of up to 24 genes, which are expressed in a range of malignant neoplasms. MAGE-1 encodes a 46 kDa protein which is expressed in a very limited range of normal tissues, in malignant melanomas and other neoplasms. Since it is detected by cytotoxic T-cells, it has been proposed as a target for immunotherapy.

Immunohistochemical expression

Normal tissues:


Diagnostic utility


Gajjar, N. A., A. J. Cochran, et al. (2004). "Is MAGE-1 Expression in Metastatic Malignant Melanomas Really Helpful?" Am J Surg Pathol 28(7): 883-8.

This page last revised 18.7.2004.

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