Muscle-specific actin (HHF35)

This antibody recognises an epitope common to alpha-skeletal, alpha-cardiac and gamma-smooth muscle actins.

Immunohistochemical expression

Diagnostic utility

Identification of smooth muscle tumours; best used in conjunction with smooth muscle actin and desmin.


Gown AM, Tsukada T,Ross R. Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol 1986; 125:191-207

Azumi N, Ben-Ezra J,Battifora H. Immunophenotypic diagnosis of leiomyosarcomas and rhabdomyosarcomas with monoclonal antibodies to muscle-specific actin and desmin in formalin-fixed tissue. Mod Pathol 1988; 1:469-74


©SMUHT/PW Bishop