Epithelioid sarcoma

The type of differentiation of epithelioid sarcoma is controversial. First thought to be histiocytic and fibroblastic, they were subsequently shown to have epithelial and myofibroblastic features. Endothelial and perineural differentiation have also been proposed: the combination of positivity for EMA, VE-cadherin, claudin-1 and GLUT-1 can be interpreted as favouring either line of differentiation2.

Definition

Epidemiology

Clinical features

Radiology

Macroscopic appearances

Histopathology

Immunohistochemistry

MNF116	9/92
Cytokeratin 1	26/371
Cytokeratin 7	17/1001
Cytokeratin 8 / 18	82/981
Cytokeratin 10	0/111
Cytokeratin 13	9/111
Cytokeratin 19	60/851
Cytokeratin 20	0/121
EMA	9/92
GLUT-1	7/82
Claudin-1	9/92
VE-cadherin	1/12
CD31	0/92
CD34	9/92
Fli-1	7/92
e-cadherin	0/82

Ultrastructure

Differential diagnosis

Management

Prognosis

References

1 Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39. (Summary data from multiple papers)

2 Smith ME, Awasthi R, O'Shaughnessy S, et al. Evaluation of perineurial differentiation in epithelioid sarcoma. Histopathology 2005; 47:575-81

This page last revised 28.2.2006.