Oesophageal epithelium

Multilayered epithelium may be derived from mucosal gland duct epithelium and may be a progenitor of Barrett's epithelium. p63 may play a role in squamous neoplasia of the oesophagus but not Barrett's metaplasia and associated neoplasia.

Immunohistochemistry

 

CK8/18

CK13

CK 14

CK19

p53

p63

  

normal squamous epithelium

0/17

18/18

19/19

16/16

0/20

20/20

dysplastic squamous epithelium

0/4

0/4

4/4

4/4

4/4

4/4

squamous carcinoma

0/7

0/7

7/7

7/7

5/7

7/7

oesophageal mucosal gland duct epithelium

10/10

3/10

0/9

10/10

 

10/11

oesophageal multilayered epithelium

9/9

6/9

0/9

9/9

4/13

9/13

intestinal metaplasia

 

 

 

 

0/10

0/10

glandular dysplasia

 

 

 

 

9/12

0/12

adenocarcinoma

 

 

 

 

4/7

0/7
 

References

Glickman, J. N., Yang, A., Shahsafaei, A., McKeon, F., Odze, R. D. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Human Pathol 2002;32:1157-1165

This page last revised 3.5.2002.

©SMUHT/PW Bishop