PDX-1, pancreatic-duodenal homeobox 1

PDX-1 is expressed in embryonic pancreatic progenitor cells.

Immunohistochemical expression

• Adult pancreatic polypeptide-secreting cells and insulin-secreting b cells

Diagnostic utility

• Differentiation of pancreatic endocrine tumours from gastrointestinal and pulmonary carcinoids.

References

1 Srivastava A,Hornick JL. mmunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumors from pancreatic endocrine and pulmonary carcinoid tumors. Am J Surg Pathol 2009; 33:626-32

This page last revised 18.4.2009.

©SMUHT/PW Bishop