Periductal stromal tumour of the breast

Definition

A rare biphasic tumour of the breast characterised by a proliferation of sarcomatous spindle cells surrounding rounded tubules and infiltrating the surrounding adipose tissue. It is distinguished from both fibroadenoma and phyllodes tumour by the lack of any foliated (leaf-like) architecture (hypercellular stroma around distorted epithelial/myoepithelial lined spaces).

Epidemiology

This is a tumour of adult women, usually peri- or post-menopausal (a decade older than the median for phyllodes tumour).

Macroscopic appearances

Histopathology

Immunohistochemistry of the stromal / sarcomatous component

           

 

CD34

CD117

HHF35

oestrogen receptor

progesterone receptor

fibroadenoma

4/41

0/41

2/41

 0/41

0/41

phyllodes tumour

3/31 , 6/72

0/31 , 1/72

2/31 , 1/72

 0/31

0/31

malignant phyllodes tumour

3/122

9/122

8/122

 0/121

0/121

periductal stromal sarcoma

13/151

6/151

2/141

0/151

0/151

periductal stromal hyperplasia

5/51

1/41

3/51

 0/51

0/51

           

Differential diagnosis

Prognosis

References

1 Burga, A.M. and Tavassoli, F.A. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. Am J Surg Pathol 2003;27:343-8.

2Chen, C.M., Chen, C.J., Chang, C.L., Shyu, J.S., Hsieh, H.F. and Harn, H.J. CD34, CD117, and actin expression in phyllodes tumor of the breast. J Surg Res 2000;94:84-91.

 

This page last revised 19.3.2003.

©SMUHT/PW Bishop