Adult renal epithelial neoplasms, overview

 

History of classification:

 

renal cell carcinoma

Second series AFIP fascicle

clear cell carcinoma

granular cell carcinoma

current classification

melanocytic clear cell neoplasm

conventional carcinoma

eosinophilic variant of conventional carcinoma

chromophobe renal cell carcinoma

renal oncocytoma

papillary renal cell carcinoma

colecting duct carcinoma

epithelioid angiomyolipoma

renal carcinoid

renal cell carcinoma, unclassified

 

Current classification:

 

 

disease-specific survival

progression-free survival

 

frequency

metastases

5-year

10-year

5-year

10-year

b
e
n
i
g
n

papillary adenoma

 

 

 

renal oncocytoma

6.7% (27/405)1

0.4% (2/~450)1*

100%

100%

100%

100%

metanephric adenoma

1/4051

 0/~1001*

 

 

m
a
l
i
g
n
a
n
t

conventional clear cell carcinoma

63% (255/405)1

37%1*, 27.4%1

76%1

70%1

70%1

64%1

papillary renal cell carcinoma

15-20%1*, 18.5% (75/405)1

6-26%1*, 12%1

82-90% of ~4021*, 86%1

82%1

88%1

83%1

chromophobe renal cell carcinoma

5-7%1*, 5.9% (24/405)1

7.1% of 3191*, 4.2%1

100%1

90%1

78-92%1*, 94%1

94%1

collecting duct carcinoma

rare

~50 of ~1001*

33% at 2 years1*

   

renal cell carcinoma, unclassified

5.7% (23/405)1

70%1

24%1

12%1

18%1

18%1

RCC combined

 

25.5%1

77%1

73%1

72%1

66%1

 

 

Histology

 

architecture

cytoplasm

nuclei

 

oncocytoma

nested, tubulocystic or mixed

uniform eosinophilic, finely granular. clear cells in regions of scarring

round, uniform chromatin, +/- nucleoli

metanephric adenoma

small tightly packed tubules, psammoma bodies, papillary structures resembling glomeruli

inconspicuous

round, uniform chromatin

conventional clear cell carcinoma

solid, alveolar , tubular, tubulocystic, pseudopapillary due to loss of cohesion, (focally papillary), fibrovascular framework, racemose vasculature

clear or eosinophilic

 

papillary renal cell carcinoma

frequently multifocal, very well circumscribed, may have fibrous capsule, papillary or tubulopapillary

eosinophilic to amphiphilic, focally clear. foam cells, necrosis and haemosiderin frequent

 

chromophobe renal cell carcinoma

alveolar, nested, solid, inconspicuous vasculature

two cell types, eosinophilic and clear, in varying proportions. clear cells have flocculent (soap-bubble) cytoplasm. May have peripheral eosinophilia with perinuclear clearing (plant cell appearance)

frequent binucleation, course chromatin, wrinkled nuclear membranes, koilocytoid atypia

collecting duct carcinoma

centred on pelvicalyceal system. tubulopapillary or tubulocystic, desmoplasia, inflammation, mucin production

eosinophilic to clear, some hobnail cells

high grade

renal cell carcinoma, unclassified

does not correspond to any of the above.

 

Sarcomatoid change may arise in all malignant cell types. Granular renal cell carcinoma is no longer a distinct subtype in this classification.

Immunohistochemistry

 

renal cell carcinoma

transitional cell carcinoma

nephrogenic adenoma

AE1/AE3

+/-

+

+

Cam5.2

+

+

+

HMW-CK

-

+

+/-

CK7

click to see details

+

+

CK20

-

+

+

EMA

+

+

+

vimentin

+

-

-

CEA

-

+

-

There has been a case report of renal type clear cell carcinoma occurring as a primary tumour in the prostate8.

 

References

7Amin, M. B., Tamboli, P., Javidan, J., Stricker, H., de-Peralta Venturina, M., Deshpande, A., Menon, M. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases. Am J Surg Pathol 2002;26:281-291. 1* indicates figure is from a review of the literature.

8Singh, H., Flores-Sandoval, N. and Abrams, J. Renal-type clear cell carcinoma occurring in the prostate. Am J Surg Pathol 2003;27:407-10.

9Mathers, M.E., Pollock, A.M., Marsh, C. and O'Donnell, M. Cytokeratin 7: a useful adjunct in the diagnosis of chromophobe renal cell carcinoma. Histopathology 2002;40:563-7.

This page last revised 30.4.2002.