History of classification:
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renal cell carcinoma |
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Second series AFIP fascicle |
clear cell carcinoma |
granular cell carcinoma |
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current classification |
melanocytic clear cell neoplasm |
conventional carcinoma |
eosinophilic variant of conventional carcinoma |
chromophobe renal cell carcinoma |
renal oncocytoma |
papillary renal cell carcinoma |
colecting duct carcinoma |
epithelioid angiomyolipoma |
renal carcinoid |
renal cell carcinoma, unclassified |
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Current classification:
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disease-specific survival |
progression-free survival |
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frequency |
metastases |
5-year |
10-year |
5-year |
10-year |
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b |
papillary adenoma |
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renal oncocytoma |
6.7% (27/405)1 |
0.4% (2/~450)1* |
100% |
100% |
100% |
100% |
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metanephric adenoma |
1/4051 |
0/~1001* |
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m |
63% (255/405)1 |
37%1*, 27.4%1 |
76%1 |
70%1 |
70%1 |
64%1 |
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papillary renal cell carcinoma |
15-20%1*, 18.5% (75/405)1 |
6-26%1*, 12%1 |
82-90% of ~4021*, 86%1 |
82%1 |
88%1 |
83%1 |
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chromophobe renal cell carcinoma |
5-7%1*, 5.9% (24/405)1 |
7.1% of 3191*, 4.2%1 |
100%1 |
90%1 |
78-92%1*, 94%1 |
94%1 |
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collecting duct carcinoma |
rare |
~50 of ~1001* |
33% at 2 years1* |
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renal cell carcinoma, unclassified |
5.7% (23/405)1 |
70%1 |
24%1 |
12%1 |
18%1 |
18%1 |
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RCC combined |
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25.5%1 |
77%1 |
73%1 |
72%1 |
66%1 |
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architecture |
cytoplasm |
nuclei |
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oncocytoma |
nested, tubulocystic or mixed |
uniform eosinophilic, finely granular. clear cells in regions of scarring |
round, uniform chromatin, +/- nucleoli |
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metanephric adenoma |
small tightly packed tubules, psammoma bodies, papillary structures resembling glomeruli |
inconspicuous |
round, uniform chromatin |
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solid, alveolar , tubular, tubulocystic, pseudopapillary due to loss of cohesion, (focally papillary), fibrovascular framework, racemose vasculature |
clear or eosinophilic |
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papillary renal cell carcinoma |
frequently multifocal, very well circumscribed, may have fibrous capsule, papillary or tubulopapillary |
eosinophilic to amphiphilic, focally clear. foam cells, necrosis and haemosiderin frequent |
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chromophobe renal cell carcinoma |
alveolar, nested, solid, inconspicuous vasculature |
two cell types, eosinophilic and clear, in varying proportions. clear cells have flocculent (soap-bubble) cytoplasm. May have peripheral eosinophilia with perinuclear clearing (plant cell appearance) |
frequent binucleation, course chromatin, wrinkled nuclear membranes, koilocytoid atypia |
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collecting duct carcinoma |
centred on pelvicalyceal system. tubulopapillary or tubulocystic, desmoplasia, inflammation, mucin production |
eosinophilic to clear, some hobnail cells |
high grade |
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renal cell carcinoma, unclassified |
does not correspond to any of the above. |
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renal cell carcinoma |
transitional cell carcinoma |
nephrogenic adenoma |
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+/- |
+ |
+ |
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+ |
+ |
+ |
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HMW-CK |
- |
+ |
+/- |
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+ |
+ |
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- |
+ |
+ |
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+ |
+ |
+ |
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|
+ |
- |
- |
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- |
+ |
- |