S100P

S100P is a member of the S100 family of proteins, first identified in placental tissue. The gene is located at 4p16. Expression may be regulated by androgen. The protein binds two calcium ions and interacts with S100Z.

Immunohistochemical expression

• Placenta

• Oesophageal squamous mucosa

• Breast carcinoma

• Pancreatic carcinoma

• Bladder carcinoma

Diagnostic utility

• Identification of urothelial neoplasms

References

1 Higgins JP, Kaygusuz G, Wang L, et al. Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol 2007; 31:673-80

This page last revised 30.5.2007.

©SMUHT/PW Bishop