SF-1, adrenal 4-binding protein

SF-1 is a nuclear transcription factor regulating gonadal and adrenal development and the genes responsible for steroidogenesis.

Immunohistochemical expression

• All types of sex cord stromal tumours1
• By the intratumoral stromal cells in a range of primary ovarian epithelial tumours and carcinomas metastatic to the ovary but not by the epithelial tumour cells themselves2

Diagnostic utility

• Diagnosis of sex cord stromal tumours1

References

1 Zhao C, Vinh TN, McManus K, Dabbs D, Barner R, Vang R. Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. Am J Surg Pathol. 2009 Mar;33(3):354-66.

2 Sasano H, Kaga K, Sato S, Yajima A, Nagura H. Adrenal 4-binding protein in common epithelial and metastatic tumors of the ovary. Hum Pathol. 1996 Jun;27(6):595-8.

This page last revised 5.4.2010.

©SMUHT/PW Bishop