Definition
The is a rare neoplasm of the salivary gland, closely resembling fibrocystic disease of the breast. Demonstration of clonality indicates that this is a true neoplasm.
It occurs from the second decade of life onwards, with a female predominance.
Most cases occur in major salivary glands, but rarely it may arise within minor salivary glands. The tumour grows slowly
The mass is well demarcated and partially encapsulated. There is a proliferation of microcysts, ducts and acini within a sclerotic stroma, with a lobular architecture. Strangulated tubules resemble sclerosing adenosis of the breast. The epithelial cells are variably apocrine, foamy, vacuolated or mucinous. There is a varying degree of cytological atypia. A continuous layer of myoepithelial cells is present around the glandular units. A focal lymphocytic infiltrate is common.
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positive in luminal epithelial cells |
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BRST-2 |
positive in luminal epithelial cells |
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positive in luminal epithelial cells |
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positive in luminal epithelial cells |
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c-erb2 |
negative in luminal epithelial cells |
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About one third of cases recur, but metastasis and death have not been reported.
1 Cheuk W,Chan JK. Advances in salivary gland pathology. Histopathology 2007; 51:1-20
This page last revised 8.7.2007.
©SMUHT/PW Bishop