Definition
An ovarian tumour showing, at least in part, a tubular pattern, analogous to Sertoli cell tumour of the testis.
Sertoli cell tumours account for only 4% of all Sertoli-stromal tumours of the ovary. Ovarian Sertoli cell tumours occur in both adults and children. Some cases are associated with Peutz-Jegher's syndrome.
Patients may show estrogenic or androgenic effects.
Tumours are unilateral, solid and usually yellow. There may be limited cystic degeneration.
The tumour cells form solid or hollow tubules, trabeculae, diffuse sheets, pseudopapillae or islands. The tumour cells usually have pale to eosinophilic cytoplasm but may be foamy (lipid-rich Sertoli cell tumour). Nuclei are typically round to oval with inconspicuous nucleoli. Nuclear grooves may be apparent. The stroma is often abundant and may be sclerotic.
Nuclear atypia and a mitotic rate greater than 5/10 HPF are associated with malignant behaviour.
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0/231 |
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19/221 |
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17/181 |
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4/181 |
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8/161 |
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2/201 |
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0/211 |
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Endometrioid carcinoma: inhibin negative, EMA positive. There are almost always areas of typical endometrioid carcinoma. Both endometrioid carcinoma and Sertoli cell tumour may have a predominance of spindle or oxyphilic cells.
Carcinoid tumour: inhibin negative, EMA positive, chromogranin positive. The acini show brush borders. The stroma is typically more fibrotic.
Sertoli-Leydig cell tumours: has more than rare Leydig cells, a retiform pattern and heterologous elements
Adult granulosa cell tumour
FATWO: more often found in the broad ligament but may occur in the ovary. Cysts and sieve-like areas are typically seen.
Steroid cell tumour: lacks a tubular pattern.
Struma ovarii: contain colloid and are associated with a dermoid cyst.
Dysgerminoma: consists of diffuse tumour cells separated by fibrous septa
Metastatic (Krukenberg) tumour
Most Sertoli cell tumours are confined to the ovary and show benign behaviour.
This page last revised 3.2.2005.
©SMUHT/PW Bishop