TRAFs are TNFR-associated factors that act downstream from Tumour Necrosis Factors. They act as signalling proteins, activating the anti-apoptotic factor kappa B (NKkB) family of transcription factors.

Immunohistochemical expression

The threshold for positivity in these studies was set at 20% of the tumour cells staining

Diagnostic utility

TRAF1 appears to be useful in combination with c-Rel.


1 Rodig SJ, Savage KJ, Nguyen V, et al. TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar lymphomas. Am J Surg Pathol 2005; 29:196-203

This page last revised 26.5.2007.

©SMUHT/PW Bishop