The Reed-Sternberg cells of classical Hodgkin's disease is commonly thought to be negative for T and B cell markers. However, immunoreactivity is not uncommon and does not exclude the diagnosis.
On frozen section1:
|
|
nodular sclerosing |
mixed cellularity |
overall |
|
CD3 (UCHT1) |
>50% RS cells: 0/14 |
>50% RS cells: 0/6 |
25% showed immunoreactivity |
|
10-50% RS cells: 2/14 |
10-50% RS cells: 0/6 |
||
|
<10% RS cells: 2/14 |
<10% RS cells: 1/6 |
||
|
no staining: 10/14 |
no staining: 5/6 |
||
|
bF1 |
>50% RS cells: 0/14 |
>50% RS cells: 0/6 |
15% showed immunoreactivity |
|
10-50% RS cells: 1/14 |
10-50% RS cells: 0/6 |
||
|
<10% RS cells: 2/14 |
<10% RS cells: 0/6 |
||
|
no staining: 11/14 |
no staining: 6/6 |
||
|
|
>50% RS cells: 0/14 |
>50% RS cells: 2/6 |
75% showed immunoreactivity |
|
10-50% RS cells: 6/14 |
10-50% RS cells: 3/6 |
||
|
<10% RS cells: 4/14 |
<10% RS cells: 0/6 |
||
|
no staining: 4/14 |
no staining: 1/6 |
||
|
|
>50% RS cells: 1/14 |
>50% RS cells: 1/6 |
80% showed immunoreactivity |
|
10-50% RS cells: 5/14 |
10-50% RS cells: 3/6 |
||
|
<10% RS cells: 6/14 |
<10% RS cells: 2/6 |
||
|
no staining: 4/14 |
no staining: 0/6 |
||
|
|
>50% RS cells: 2/14 |
>50% RS cells: 0/6 |
60% showed immunoreactivity |
|
10-50% RS cells: 3/14 |
10-50% RS cells: 3/6 |
||
|
<10% RS cells: 3/14 |
<10% RS cells: 1/6 |
||
|
no staining: 6/14 |
no staining: 2/6 |
On paraffin section1:
|
|
nodular sclerosing |
mixed cellularity |
overall |
|
CD3 (UCHT1) |
>50% RS cells: 0/45 |
>50% RS cells: 0/10 |
9% showed immunoreactivity |
|
10-50% RS cells: 1/45 |
10-50% RS cells: 0/10 |
||
|
<10% RS cells: 4/45 |
<10% RS cells: 0/10 |
||
|
no staining: 40/45 |
no staining: 10/10 |
||
|
bF1 |
>50% RS cells: 0/45 |
>50% RS cells: 0/10 |
0% showed immunoreactivity |
|
10-50% RS cells: 0/45 |
10-50% RS cells: 0/10 |
||
|
<10% RS cells: 0/45 |
<10% RS cells: 0/10 |
||
|
no staining: 45/45 |
no staining: 10/10 |
||
|
|
>50% RS cells: 11/45 |
>50% RS cells: 0/10 |
58% showed immunoreactivity |
|
10-50% RS cells: 4/45 |
10-50% RS cells: 5/10 |
||
|
<10% RS cells: 10/45 |
<10% RS cells: 2/10 |
||
|
no staining: 20/45 |
no staining: 3/10 |
||
|
|
>50% RS cells: 5/45 |
>50% RS cells: 1/10 |
55% showed immunoreactivity |
|
10-50% RS cells: 8/45 |
10-50% RS cells: 3/10 |
||
|
<10% RS cells: 9/45 |
<10% RS cells: 4/10 |
||
|
no staining: 23/45 |
no staining: 2/10 |
||
|
|
|
23/312 |
|
|
MB2 |
>50% RS cells: 1/45 |
>50% RS cells: 0/10 |
33% showed immunoreactivity |
|
10-50% RS cells: 4/45 |
10-50% RS cells: 5/10 |
||
|
<10% RS cells: 7/45 |
<10% RS cells: 1/10 |
||
|
no staining: 33/45 |
no staining: 4/10 |
References