Differential of spindle cell tumours of the pleura

CD34

bcl-2

CD99

cytokeratin

EMA

calretinin

desmin

SMA

SFT

+

+

+

-

-

-

some, focally

rare, focally

desmoid tumour

-

-

-

+

+

sarcomatoid mesothelioma

-

some

some

+

+

+

some

+

synovial sarcoma

-

+

variable

+

+

pleural thymoma, WHO type A

-

some

lymphocytes only

+

-

stromal cells only

smooth muscle tumour

some

some

some

+

+

haemangiopericytoma

+

variable

- 

 -

neurofibroma

most

+

schwannoma

some

+

malignant peripheral nerve sheath tumour

rare

some

rare(may be cytokeratin positive if epithelioid areas are present)

  rare(may be positive if rhabdomyoblastic areas are present)

   rare(may be positive if rhabdomyoblastic areas are present)

spindle cell lipoma

+

+

calcifying fibrous pseudotumour

variable

-

-

-